α-Synuclein potentiates interleukin-1β-induced CXCL10 expression in human A172 astrocytoma cells

► A low concentration of IL-1β (250 pg/ml) induces NF-κB activation and CXCL10 expression in human astroglial cells. ► Co-exposure to α-synuclein potentiates IL-1β-induced CXCL10 protein expression. ► α-Synuclein does not alter IL-1β-induced NF-κB activation. ► α-Synuclein mediates an increase in CXCL10 mRNA stability, which may account for increased CXCL10 protein expression.