| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4344908 | Neuroscience Letters | 2011 | 6 Pages |
Abstract
⺠SIRT1 activation deficiency was found in the VSC-4.1-hSOD1G93A cells. ⺠Protective effects of resveratrol were blocked by the SIRT1 inhibition. ⺠Effects of resveratrol by SIRT1 modulation indicated a therapeutic target for ALS.
Keywords
hSOD1PGC1-αDMEMFBSMFN2MAP2sirtuinSirt13-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDulbecco's modified Eagle's mediumMTTNAD+amyotrophic lateral sclerosisALSMitochondria biogenesisResveratrolfetal bovine serumSilent mating type information regulation 2 homolog 1mitofusin 2Neurofilamentswild typeNAD, nicotinamide adenine dinucleotideNicotinamideMicrotubule associated protein 2Propidium iodide
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Authors
Jing Wang, Yun Zhang, Lu Tang, Nan Zhang, Dongsheng Fan,