| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345006 | Neuroscience Letters | 2011 | 5 Pages |
Abstract
⺠Combination of non-toxic doses of methamphetamine and caffeine significantly reduces the viability of SK-N-SH cells. ⺠Combination of methamphetamine and caffeine increases the ROS production and Bax/Bcl-2 ratio in SK-N-SH cells. ⺠Co-administration of methamphetamine and caffeine decreases the survival rate of rats and increases the TBARS levels in striatal tissues. ⺠The results indicate that caffeine potentiates the toxic effects of methamphetamine both in vitro and in vivo.
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Authors
Theerin Sinchai, Surin Plasen, Yupin Sanvarinda, Yamaratee Jaisin, Piyarat Govitrapong, Noppawan Phumala Morales, Piyanee Ratanachamnong, Duangporn Plasen,