Adenosine monophosphate-activated protein kinase and peroxisome proliferator-activated receptor gamma coactivator 1Î± signaling provides neuroprotection in status epilepticus in rats

Article ID	Journal	Published Year	Pages	File Type
4345123	Neuroscience Letters	2011	6 Pages	PDF

Abstract

âº Pilocarpine-induced SE stimulates AMPK,PGC-1a and UCP2. âº Activation of PGC-1a and UCP2 is AMPK dependent after SE. âº Activation of AMPK/PGC-1a signaling pathway may be neuroprotective after SE.

Keywords

MDA UCP PGC-1α AMPK GSH DMSO ROS status epilepticus compound C Oxidative stress Dimethylsulfoxide malondialdehyde Neuroprotection peroxisome proliferator-activated receptor gamma coactivator 1α uncoupling protein 2 Uncoupling protein adenosine monophosphate-activated protein kinase Glutathione Reactive oxygen species Peroxisome proliferator-activated receptor gamma coactivator-1α