| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345133 | Neuroscience Letters | 2011 | 4 Pages |
It is well known that hippocampus plays important roles in learning and memory. Both calcitonin gene-related peptide (CGRP) and CGRP receptors are found in hippocampus. In the present study we explored the influence of CGRP on long term potentiation (LTP) in hippocampal Schaffer collateral-CA1. Our results demonstrated that CGRP inhibited the LTP induced by high frequency stimulation (HFS) in hippocampal CA1 neurons in rat brain slices. The inhibitory effect was blocked by CGRP receptor-1 antagonist CGRP 8-37. The results indicate that both CGRP and CGRP receptor 1 are involved in the modulation process of LTP in hippocampus of rats.
► CGRP inhibits the HFS-induced LTP in hippocampal CA1 slices. ► The CGRP-induced inhibition on LTP is blocked by CGRP antagonist CGRP 8-37. ► CGRP and CGRP receptor 1 are involved in learning and memory in hippocampus.
