| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345171 | Neuroscience Letters | 2011 | 5 Pages |
Abstract
⺠Inhibition of sphingosine kinase 1 and 2 prevents ceramide-induced hyperalgesia. ⺠Inhibition of TNF-α signaling reduces ceramide-induced hyperalgesia. ⺠The S1P receptor 1 antagonist, W146, blocks ceramide-induced hyperalgesia. ⺠The S1P pathway may be a novel therapeutic approach in pain management.
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Authors
Tim Doyle, Zhoumou Chen, Lina M. Obeid, Daniela Salvemini,