| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345208 | Neuroscience Letters | 2011 | 4 Pages |
Abstract
⺠The relative contribution of MOR activation to tapentadol-induced analgesia was determined. ⺠OPRM1 knockout mice were used. ⺠Tapentadol show a 10-fold higher potency in chronic neuropathic as compared to acute pain. ⺠Activation of MOR only partially contributes to the analgesic effect. ⺠The remaining antinociceptive activity in OPRM1 KO mice was abolished by yohimbine.
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Authors
Babette Kögel, Jean De Vry, Thomas M. Tzschentke, Thomas Christoph,