Article ID Journal Published Year Pages File Type
4345219 Neuroscience Letters 2011 5 Pages PDF
Abstract
▶ A plus-maze test detects onset and recovery of spatial working memory deficits after TBI. ▶ Pre-trial pyruvate treatment attenuates cognitive deficits in rats with TBI. ▶ Cerebral glycolysis remains depressed 2 weeks after cortical contusion injury in the rat. ▶ Cerebral cytochrome oxidase activity recovers within 2 weeks after cortical contusion injury. ▶ Delayed pyruvate treatment did not affect measures of cerebral metabolism 2 weeks post-injury.
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