Analysis of mutations and the association between polymorphisms in the cerebral dopamine neurotrophic factor (CDNF) gene and Parkinson disease

► We failed to identify any mutations in CDNF in 110 early-onset Parkinson disease. ► A trend towards increased risk for PD in those carrying the C allele at rs7094179. ► C allele at rs7094179 was susceptible for PD in dominant and recessive models. ► C allele of an intronic CDNF SNP, rs7094179 may be a susceptibility allele for PD.