| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345333 | Neuroscience Letters | 2011 | 4 Pages |
Abstract
⺠Rp-8-Br-cAMPS (a selective inhibitor of protein kinase A) acts antidepressant-like in the rat forced swim test. ⺠Rp-8-Br-cAMPS increases cerebellar CREB phosphorylation. ⺠Rp-8-Br-cAMPS increases cAMP and cGMP in several brain areas. ⺠The antidepressant-like effects of this drug may be mediated by a PKA-independent mechanism(s) such as Epac.
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Authors
Nico Liebenberg, Heidi Kaastrup Müller, Christina Weide Fischer, Brian H. Harvey, Christiaan B. Brink, Betina Elfving, Gregers Wegener,