Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4345394 | Neuroscience Letters | 2011 | 5 Pages |
Abstract
â¶ Domoic acid is an excitotoxin that induces COX2 expression in the brain. â¶ Properly dosed COX2 inhibitors protect sensitive CA1 and CA3 neurons from excitotoxicity. â¶ Properly dosed COX2 inhibitors provide protection against lethality of excitotoxicity. â¶ Improper dosing of COX2 inhibitors can aggravate domoic acid excitotoxicity.
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Authors
James C. Ryan, Cheryl A. Cross, Frances M. Van Dolah,