Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4345513 | Neuroscience Letters | 2011 | 6 Pages |
Abstract
â¶ The life time of PrPC is cleaved as a normal protein or it is uncleaved as an abnormal protein, PrPSc. â¶ This is the first report of real-time imaging of protein cleavage process of PrP. â¶ The real-time imaging revealed that calpastatin drastically inhibited endoproteolysis of PrPC. â¶ Calpain-like activity mediates normal processing of PrPC.
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Authors
Naomi Hachiya, Yuko Komata, Sana Harguem, Kana Nishijima, Kiyotoshi Kaneko,