| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345525 | Neuroscience Letters | 2010 | 4 Pages |
Repeated administration of amphetamine (AMPH) can produce behavioral sensitization. However, whether contextual elements and housing conditions influence AMPH-induced behavioral sensitization remains uncertain. This study was designed to examine the effects of housing conditions (single- vs. group-housed) and different contextual changes, including social (with two other co-drug partners) and physical (novel box) context changes, on AMPH-induced behavioral sensitization. During the training phase, all rats were exposed for 7 days to AMPH (1 mg/kg, intraperitoneally) in a Locometer chamber, with the exception of animals tested for the effects of physical context changes trained in a novel box. Following a 7-day withdrawal phase, all rats received an AMPH (0.5 mg/kg) challenge, and locomotor activity in a Locometer box was recorded before and after AMPH injection during the testing phase. Under group housing conditions, animals exposed to a different physical environment between the training and testing phases or accompanying co-drug partners during the training phase exhibited decreased AMPH-induced locomotor sensitization. In contrast, single housing conditions did not have an inhibitory effect on AMPH-induced behavioral sensitization after manipulations of the physical and social contexts. These results suggest that under group housing conditions, both physical and social context changes can attenuate AMPH-induced behavioral sensitization. The possible neural mechanisms underlying the involvement of different housing conditions in AMPH-induced behavioral sensitization are discussed.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (89 K)Download as PowerPoint slideResearch highlights▶ Overall, social context change (e.g., drug-use with partners) decreased behavioral sensitization. ▶ The group housing condition decreased behavioral sensitization regardless of physical or social context change groups. ▶ The single housing condition did not occur the inhibition effect. ▶ Suggested neural mechanisms mediating behavioral sensitization offer an application in clinic.
