Olfactory enseathing glia enhances reentry of axons into the brain from peripheral nerve grafts bridging the substantia nigra with the striatum

► Peripheral nerve grafts permit bridge lesions in the CNS, but they not permit the exit of axons. ► Olfactory enseathing glia (OEG) may solve this problem. ► We compared peripheral nerve grafts to reconstruct the nigrostriatal pathway with or without OEG. ► OEG permitted a higher fiber density inside the graft and more axons exiting the grafts. ► This may be relevant to apply grafts to central nervous system reconstruction in several diseases.