| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4345744 | Neuroscience Letters | 2010 | 4 Pages |
Abstract
ⶠRepeated administration of morphine induces opioid tolerance. ⶠOpioid tolerance is related to the activation of glycogen synthase kinase 3β. ⶠGlycogen synthase kinase 3β is suppressed by valproate. ⶠValproate attenuates the development of morphine antinociceptive tolerance.
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Authors
Tamae Dobashi, Serabi Tanabe, Hisayo Jin, Takashi Nishino, Tomohiko Aoe,