Regio- and stereoselective synthesis of β-amino alcohols over titanosilicate molecular sieves

A novel application of titanosilicate molecular sieves in the synthesis of β-amino alcohols via aminolysis of epoxides, at mild and solvent-free conditions, is reported, for the first time. A range of β-amino alcohols with nearly 100% regio- and stereoselectivity was produced over these reusable solid catalysts in high yields.

Graphical abstractA novel application of titanosilicate molecular sieves in the synthesis of β-amino alcohols via aminolysis of epoxides, at mild and solvent-free conditions, is reported, for the first time. A range of β-amino alcohols with nearly 100% regio- and stereoselectivity was produced over these reusable solid catalysts in high yields.Figure optionsDownload full-size imageDownload as PowerPoint slide