Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4346507 | Neuroscience Letters | 2010 | 5 Pages |
Abstract
Astrocytes accumulate iron under chronic oxidative stress conditions in ageing and neurological disorders. The soybean isoflavone genistein possesses antioxidant properties and selective estrogen-like activities. Here, a possible role of genistein in modulation of iron transport was explored in glial cells. Genistein significantly increased iron export through estrogen receptor-β-dependent p38 MAPK activation. Evidence is presented that this effect is associated to a p38 MAPK-triggered up-regulation of the iron export system made by ceruloplasmin and ferroportin-1, a pathway requiring activation of the transcription factor C/EBP.
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Authors
Tiziana Persichini, Nunziata Maio, Maria Carmela Bonaccorsi di Patti, Gianluca Rizzo, Marco Colasanti, Giovanni Musci,