| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4346983 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
There is growing evidence that low vitamin D impacts adversely on brain development. The current study investigated the impact of developmental vitamin D (DVD) deficiency on dopamine and serotonin metabolism in the neonatal rat brain. DVD-deficiency resulted in an altered dopaminergic metabolic profile in the forebrain, with a decrease in the conversion of dihydroxyphenylacetic acid (DOPAC) to homovanillic acid (HVA). Correspondingly, expression of the enzyme required for this conversion, catechol-O-methyl transferase (COMT), was decreased. These results suggest that DVD-deficiency influences dopamine turnover during development.
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Authors
James P. Kesby, Xiaoying Cui, Pauline Ko, John J. McGrath, Thomas H.J. Burne, Darryl W. Eyles,