Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4346988 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
A recent study reported that variants of the neuronal sortilin-related receptor gene (SORL1) increased the risk of late-onset Alzheimer disease (AD) in several populations. Here, we examined the risk effect in a large, well-characterized group of 437 late-onset AD patients and 451 control subjects in a Japanese population. Among eight single-nucleotide polymorphisms (SNPs) of the SORL1 gene for which association has been reported, we found a significant association for four of them, located between exon 24 and intron 37. This risk was evident in non-carriers of the apolipoprotein E-ɛ4 allele, but not in its carriers. Our results support the evidence that genetic variants of SORL1 affect susceptibility to late-onset AD.
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Authors
Ryo Kimura, Mitsuko Yamamoto, Takashi Morihara, Hiroyasu Akatsu, Takashi Kudo, Kouzin Kamino, Masatoshi Takeda,