| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4347098 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
Recently, the DAOA gene locus on chromosome 13q32–q34 has been implicated in the etiology of schizophrenia. We genotyped three single-nucleotide polymorphisms (SNPs: rs778294, rs779293 and rs3918342) in this region in 126 Chinese family trios. In this study, we have identified statistically significant transmission disequilibrium in two markers rs778293 (P = 0.01) and rs3918342 (P = 0.02), and a highly significant under-transmission between haplotype CAT (P = 0.0005) and schizophrenia. The results provide further evidence to support that DAOA gene locus is involved in conferring susceptibility to schizophrenia.
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Authors
Jie Ma, Jian Sun, Huan Zhang, Rui Zhang, Wan-Hu Kang, Cheng-Ge Gao, Hai-Sheng Liu, Xue-Hong Ma, Zi-Xin Min, Wen-Xiang Zhao, Qi-Lan Ning, Shu-Hong Wang, Yin-Cang Zhang, Ting-Wei Guo, She-Min Lu,