Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4347353 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
Hemimegalencephaly is a rare brain malformation whose physiology is largely obscure. In a single patient, we studied motor cortex using several transcranial magnetic stimulation variables testing cortical excitability, and mapping motor area. The megalencephalic hemisphere showed an enlargement of cortical motor map with abnormal axonal orientation and an excess spread of corticospinal excitation, associated with multiple defects of cortical inhibition. TMS gave new information on the anatomic/functional features and epileptogenesis in this complex and physiologically obscure syndrome.
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Authors
Carlo Civardi, Roberta Vicentini, Alessandra Collini, Cristina Boccagni, Roberto Cantello, Francesco Monaco,