Article ID Journal Published Year Pages File Type
4347492 Neuroscience Letters 2009 5 Pages PDF
Abstract
Ultrasonic vocalization at 55 kHz (55 kHz-USVs) by rodents has been proposed to be a behavioral manifestation of affectively positive incentive motivation. To examine the extent to which 55 kHz-USV emissions correlate with cocaine-induced locomotor activity, we measured cocaine-induced 55 kHz-USVs and their relationship to cocaine-induced locomotor sensitization in rats. We demonstrate that similar to locomotor responses, 55 kHz-USVs are also sensitized by exposure to cocaine. Furthermore, we show that the magnitude of cocaine-induced 55 kHz-USV sensitization is positively correlated with that of locomotor sensitization. Moreover, we demonstrate that rats selectively bred for high rates of 55 kHz-USVs exhibit higher levels of cocaine-induced 55 kHz-USV sensitization than animals selectively bred for low levels of 55 kHz USVs. These results suggest that the neural circuits underlying 55 kHz-USV, which may directly reflect affective experience/motivation, can be sensitized by cocaine in a way that resembles locomotor sensitization.
Related Topics
Life Sciences Neuroscience Neuroscience (General)
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