| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4347497 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
Results of our work suggest that P-glycoprotein (P-gp) overexpression by repetitive seizures induced by MP administration does not modify brain bioavailability of carbamazepine. Conversely, hippocampal levels of phenobarbital are reduced in MP rats with regard to non-epileptic rats, suggesting a potential role of P-gp overexpression in pharmacoresistance to phenobarbital.
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Authors
Christian Höcht, Alberto Lazarowski, Nélida N. Gonzalez, Marcos A. Mayer, Javier A.W. Opezzo, Carlos A. Taira, Elena Girardi,