Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4347717 | Neuroscience Letters | 2008 | 4 Pages |
Abstract
Reactive oxygen species (ROS) are implicated in the pathogenesis of multiple sclerosis (MS) and its murine model experimental autoimmune encephalomyelitis (EAE). The effect of edaravone, a free radical scavenger, on EAE was investigated in this study. Treatment with edaravone significantly ameliorated the clinical severity of EAE, and a reduced infiltration of lymphocytes was observed based on a histological analysis. The expression of inducible NO synthase (iNOS) in the spinal cords appeared to be reduced by the treatment with edaravone and this effect was confirmed in vitro. A reduction of both the cellular infiltration and the expression of iNOS may therefore underlie the mechanisms of the beneficial effect of edaravone on EAE.
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Neuroscience
Neuroscience (General)
Authors
Masayuki Moriya, Yuji Nakatsuji, Katsuichi Miyamoto, Tatsusada Okuno, Makoto Kinoshita, Atsushi Kumanogoh, Susumu Kusunoki, Saburo Sakoda,