| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4347960 | Neuroscience Letters | 2009 | 4 Pages |
Abstract
Whole-cell patch clamp technique was used to study the modulatory effect of Cholecystokin-8S (CCK-8S), a neuropeptide, on NMDA-activated current (INMDA) in cultured rat hippocampal neurons under condition of normal and ethanol exposure. Our study showed that CCK-8S inhibited INMDA in a non-concentration and non-competition dependent manner. Ethanol significantly inhibited INMDA, and CCK-8S further inhibited INMDA. Our results suggest that CCK-8S is an inhibitory modulator of NMDA receptors under normal and ethanol exposure conditions.
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Authors
Xiaofei Wei, Zhongshuang Zhang, Lei Zhao, Junqiang Si,