| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4349014 | Neuroscience Letters | 2007 | 6 Pages |
Abstract
Oxidized glutathione C60 derivative has been synthesized and characterized in our research. As a novel derivative of C60, the glutathione C60 derivative is soluble in dimethylsulfoxide, dimethylformamide and dimethylacetamide. Rat pheochromocytoma (PC12) cells are treated with hydrogen peroxide and underwent cytotoxicity; apoptotic death is determined by MTT assay, flow cytometry analysis, PI/Hoechst 33342 staining and glutathione assay. The results suggest that glutathione C60 derivative has the potential to prevent oxidative stress-induced cell death without evident toxicity.
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Neuroscience
Neuroscience (General)
Authors
Zhen Hu, Shenghong Liu, Yen Wei, Etang Tong, Fei Cao, Wenchao Guan,