| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4349218 | Neuroscience Letters | 2007 | 4 Pages |
Abstract
Our previous study demonstrated that successive electroacupuncture (EA) at ST36 acupoint reduces IgE production in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH) by suppression of the Th2 cell lineage development. Here, we report that pretreatment of phentolamine (α-adrenoceptor antagonist, 10 mg/kg, i.p.) completely blocks the EA-induced suppression of antigen-specific and total IgE levels in serum and IL-4 production in anti-CD3 mAb-activated splenocytes in DNP-KLH immunized mice. The results suggest that α-adrenoceptor play an important role in mediating the suppressive effects of EA on IgE production and Th2 cell response in DNP-KLH immunized mice.
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Authors
Youngseop Lee, Sun Kwang Kim, Yangseok Kim, Hyejung Lee, Min-Kyu Shin, Moo-Chang Hong, Byung-Il Min, Hyunsu Bae,