Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4349511 | Neuroscience Letters | 2007 | 5 Pages |
Abstract
Pain consists of sensory and negative affective components. Using a conditioned place aversion (CPA) paradigm, we investigated whether the medial thalamus (MT) played a role in the affective component of visceral pain induced by intraperitoneal injection of acetic acid into male Long–Evan rats. Acetic acid produced writhing response as well as CPA. The bilateral MT-lesions resulted in slight reduction of writhing response, but CPA was not affected. The results suggest that while MT may play a role in visceral nociception, it does not participate in the negative affective component of visceral pain.
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Authors
Han-Cheng Wang, Sin-Chee Chai, Yen-Sheng Wu, Chia-Chuan Wang,