| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4349819 | Neuroscience Letters | 2007 | 5 Pages |
Abstract
The present study was undertaken to determine if the neuroprotective effect of 17β-estradiol (E2) when administrated after ischemia is dose-dependent and if the therapeutic window for estrogen can be prolonged. Ischemic injury was induced by permanent middle cerebral artery occlusion (p-MCAO). Administration of E2 at 30 min after ischemia resulted in a reduction in lesion volume. A higher dose of E2 extended the therapeutic window to 6 h after cerebral ischemia in 33% of the rats. These findings suggest that postischemic treatment with estrogen affords protection against ischemic damage and that it acts within a clinically useful therapeutic window.
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Authors
Ran Liu, Xiaofei Wang, Qing Liu, Shao-Hua Yang, James W. Simpkins,