Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4350245 | Neuroscience Letters | 2006 | 4 Pages |
Abstract
The aim of this study was to investigate the relationship between the functional C957T single-nucleotide polymorphism of the dopamine D2 receptor (DRD2) gene and the risk for schizophrenia. We therefore conducted a case-control association study of 188 Finnish schizophrenia patients meeting the DSM-IV criteria and 384 healthy controls. The 5â² nuclease assay (TaqMan) was used to determine genotypes. A greater proportion of patients with schizophrenia than healthy controls were C-allele carriers (odds ratio 1.5, 95% confidence interval (CI) 1.0-2.3, PÂ =Â 0.05). Our results are in agreement with an earlier association study suggesting that the C957T C-allele plays a role in the genetic vulnerability for schizophrenia and support the involvement of the DRD2 gene in schizophrenia pathogenesis.
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Authors
Kari Hänninen, Heikki Katila, Olli Kampman, Sami Anttila, Ari Illi, Riikka Rontu, Kari M. Mattila, Jarmo Hietala, Mikko Hurme, Esa Leinonen, Terho Lehtimäki,