| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4350419 | Neuroscience Letters | 2006 | 5 Pages |
Abstract
The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.
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Authors
Phullara B. Shelat, Aminata P. Coulibaly, Qun Wang, Albert Y. Sun, Grace Y. Sun, Agnes Simonyi,