| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4350647 | Neuroscience Letters | 2006 | 5 Pages |
Abstract
The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10Â mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Sung-Woo Park, Sun-Kyung Lee, Jae-Min Kim, Jin-Sang Yoon, Young-Hoon Kim,