Article ID Journal Published Year Pages File Type
4350818 Neuroscience Letters 2006 4 Pages PDF
Abstract

β-arrestin 2 plays important physiological roles in regulating the function of the μ opioid receptor (μOR) in vivo. Periaqueductal gray (PAG) is a potential structure where morphine produces its antinociception, but it is unclear whether β-arrestin 2 plays its regulatory effect on morphine at PAG. In the present study β-arrestin 2 overexpression was induced by adenovirus at PAG of rats. Morphine was administrated in these rats through PAG microinjection and systemic administration. The antinociceptive effects of morphine were abolished in rats received microinjection of morphine at PAG and partially attenuated in rats received systemic administration of morphine. These findings support the notion that PAG is an important site where β-arrestin 2 plays its regulatory effects on morphine analgesia.

Related Topics
Life Sciences Neuroscience Neuroscience (General)
Authors
, , , , ,