Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4350940 | Neuroscience Letters | 2006 | 4 Pages |
In order to evaluate the roles of the vestibular system in controlling arterial pressure (AP) during exposure to a short period of microgravity (μG), the AP was measured in conscious free-moving rats having intact vestibular systems and those having vestibular lesions (FM-Intact and FM-VL groups, respectively). During free drop-induced μG, the AP increased in the FM-Intact group; it was 38 ± 4 mmHg more than the AP observed during 1 G. However, the increase in AP was significantly lower in the FM-VL group (20 ± 2 mmHg). Further, to examine the sudden effect of a body floating in the midair in response to the AP during exposure to μG a body stabilizer was placed on the back of rats having intact vestibular systems and those having vestibular lesions (STAB-Intact and STAB-VL groups, respectively). The increase in the AP was significantly depressed in the STAB-Intact group; when compared with that in the FM-Intact group, but the increase was still significant (27 ± 2 mmHg). On the other hand, the increase in the AP was completely eliminated in the STAB-VL group (7 ± 5 mmHg). These results indicate that the AP increases during exposure to μG in conscious rats, and the vestibular system and body stability are significantly involved in this response.