Multiple patterns of spatiotemporal changes in layer-specific gene expression in the developing visual cortex of higher mammals

Article ID	Journal	Published Year	Pages	File Type
4351492	Neuroscience Research	2012	11 Pages	PDF

Abstract

âº The visual cortex undergoes synaptogenesis in a layer-specific manner. âº Synaptogenesis needs predetermined programs and experience-dependent reorganization. âº We identified seven genes with layer-specific expression. âº One gene, APLP1, might mediate predetermined programs during synaptogenesis. âº Another gene, STMN2, may reorganize cortical layers via microtubule-related effects.

Keywords

LAMB2 Synaptic connection APP pKa STMN2 TPI1 CaM kinase IV SCG10 cdk5 APLP1 GPx1 BDNF MAPK synapse formation Critical period digoxigenin postnatal day Ocular dominance column cyclin-dependent kinase 5 DIG Brain-derived neurotrophic factor monocular deprivation amyloid precursor protein mitogen-activated protein kinase cAMP-dependent protein kinase Dark rearing glutathione peroxidase 1