Single prolonged stress enhances hippocampal glucocorticoid receptor and phosphorylated protein kinase B levels

Article ID	Journal	Published Year	Pages	File Type
4351744	Neuroscience Research	2013	8 Pages	PDF

Abstract

âº Single prolonged stress (SPS) enhances hippocampal glucocorticoid receptor (GR) levels. âº SPS increases phosphorylated Akt in the hippocampus coincident with GR increases. âº SPS does not produce unconditioned anxiety-like behavior or disrupt spontaneous locomotor activity.

Keywords

GSK3 PI3K pAkt SPS mTOR ERK EPM MAPK Akt Posttraumatic stress disorder PTSD Anxiety elevated plus maze Single prolonged stress phosphorylated Akt phosphoinositide 3-kinase Open field mammalian target of rapamycin Hippocampus protein kinase B extracellular signal-related kinase mitogen-activated protein kinases glycogen synthase kinase 3 glucocorticoid receptor