Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4352125 | Neuroscience Research | 2011 | 9 Pages |
Abstract
⺠We stably expressed mutant NMDAR on HEK 293T cell surface. ⺠Autoantibodies from anti-NMDAR encephalitis patients recognize extracellular epitopes of GluRzeta1 subunit and induce internalization of it. ⺠The specificity of the on-cell Western was improved at 37 °C. ⺠Our assays will be valuable for the diagnosis, evaluation of clinical treatments, and follow up of anti-NMDAR encephalitis.
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Neuroscience (General)
Authors
Shiho Takano, Yukitoshi Takahashi, Hiroyuki Kishi, Yoshiharu Taguchi, Shutaro Takashima, Kortaro Tanaka, Atsushi Muraguchi, Hisashi Mori,