Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4352436 | Neuroscience Research | 2008 | 5 Pages |
Abstract
We examined whether central or peripheral administration of interleukin-1β (IL-1β) might change levels of nitric oxide (NO) and hydroxyl radical (OH) in the medial prefrontal cortex (mPFC). Extracellular levels of NO metabolites (NOxâ) and 2,3-dihydroxybenzoic acid (2,3-DHBA), as a marker of OH production, were determined with an in vivo microdialysis technique in conscious rats. In the mPFC, central administration of IL-1β into the mPFC resulted in dose-dependent increases in levels of both NOxâ and 2,3-DHBA. In contrast, peripheral administration of IL-1β significantly increased NOxâ levels but not 2,3-DHBA levels. Perfusion of Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, a superoxide (O2â) dismutase mimic, into the mPFC reduced the increases in levels of 2,3-DHBA induced by centrally administered IL-1β, but enhanced the increases in levels of NOxâ induced by centrally administered IL-1β. The present results show a different response in free radical productions in the mPFC between central and peripheral administration of IL-1β. This finding should be useful for our understanding of the response of NO and free radicals such as OH and O2â in the mPFC after central and peripheral administration of IL-1β.
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Authors
Yuta Ishizuka, Hiroshi Abe, Hideyuki Nakane, Hiroshi Kannan, Yasushi Ishida,