| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4352738 | Neuroscience Research | 2009 | 4 Pages |
Abstract
Cocaine- and amphetamine-regulated transcript (CART) peptide regulates appetite, reward, and mood. CART expression is regulated via the protein kinase A (PKA) pathway, and electroconvulsive shock (ECS), an efficient antipsychotic and antidepressant measure, activates PKA-related signaling. Thus, we hypothesized that ECS may regulate the expression of CART. ECS given daily for five consecutive days increased CART mRNA and protein in the rat nucleus accumbens (NAc), accompanied by an increase in CREB phosphorylation. Our results suggest that ECS-induced CART up-regulation might be associated with PKA-CREB signaling, but the causal direction remains to be elucidated in future studies.
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Myoung-Sun Roh, Feng Ji Cui, Yong Min Ahn, Ung Gu Kang,