Cannula-aided penetration: A simple method to insert structurally weak electrodes into brain through the dura mater

We developed a simple and inexpensive method to insert structurally weak electrodes into the brain through the thickened dura mater in chronic animal experiments. It uses a commonly available intravenous (IV) needle and a cannula to secure a small puncture in the dura mater, through which an electrode is advanced into the underlying cerebral cortex. In addition to its simplicity and cost-effectiveness, this method provides greater degree of freedom regarding the shape and the placement of electrodes compared to the conventional guide tube systems.