Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4352998 | Neuroscience Research | 2008 | 4 Pages |
Abstract
Natural antisense transcripts and overlapping sense transcripts are expressed in a variety of tissues, including adult mouse brain. Here we show that a subset of mRNA-like sense–antisense transcript pairs are co-expressed within synaptoneurosomes of adult mouse forebrain, a subcellular fraction that is enriched in pinched-off dendritic spines of pyramidal neurons. Several of these pairs involve mRNAs that have been implicated in synaptic functions and in Alzheimer disease pathways. This study provides evidence that a new class of noncoding RNAs (natural antisense transcripts) are expressed near synapses, and encourages further studies of their roles in neuronal function.
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Authors
Neil R. Smalheiser, Giovanni Lugli, Vetle I. Torvik, Nathan Mise, Rieko Ikeda, Kuniya Abe,