Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353202 | Neuroscience Research | 2006 | 9 Pages |
Abstract
We found reduced locomotor activity (LA) under fasting in systemic carnitine-deficient juvenile visceral steatosis (jvsâ/â) mice. When food was withdrawn at 8:00Â a.m. (lights-off at 7:00Â p.m., 12Â h/cycle), the nocturnal LA of jvsâ/â mice was much less than the control (jvs+/+ and jvs+/â) mice. LA recovered under carnitine or sucrose administration, but not under medium-chain triglyceride. In addition, fasted jvsâ/â mice, without any energy supply, were activated by modafinil, a stimulator of the dopamine pathway. These results suggest that the reduced LA is not adequately explained by energy deficit. As the fasted jvsâ/â mice showed lower body core temperature (BT), we examined the central nervous system regulating LA and BT. We found lower percentage of c-Fos positive orexin neurons in the lateral hypothalamus and reduced orexin-A concentration in the cerebrospinal fluid of fasted jvsâ/â mice. Sleep analysis revealed that fasted jvsâ/â mice had disruption of prolonged wakefulness, with a higher frequency of brief episodes of non-REM sleep during the dark period than fasted jvs+/+ mice. These results strongly suggest that the reduced LA in fasted jvsâ/â mice is related to the inhibition of orexin neuronal activity.
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Authors
Goichiro Yoshida, Meng Xian Li, Masahisa Horiuchi, Shiro Nakagawa, Mie Sakata, Satoshi Kuchiiwa, Toshiko Kuchiiwa, Md. Abdul Jalil, Laila Begum, Yao Bang Lu, Mikio Iijima, Takeshi Hanada, Masamitsu Nakazato, Zhi-Li Huang, Naomi Eguchi, Keiko Kobayashi,