Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353345 | Progress in Neurobiology | 2014 | 20 Pages |
Abstract
Affective disorders and cognitive deficits are common comorbidities of chronic pain in the clinical setting, which severely affect the quality of life of pain patients and impose a great difficulty upon clinical pain therapy. Despite large numbers of human studies examining this issue, there are surprisingly few reports investigating the comorbidities of chronic pain in animal models. This review summarizes and integrates previous reports of animal studies on pain and comorbidity, covering pain-evoked anxiety, depression, attentional deficits, cognitive impairment and locomotor dysfunction in rodents. Moreover, pain-induced alterations in synaptic plasticity are also discussed in terms of long-term potentiation and long-term depression, synaptic transmission, neuronal excitability and structural correlates in 'pain matrix'. Finally, we conclude this review by pointing out some unresolved problems and future research directions.
Keywords
EPSPsCRFFSTSNLSTZCCIPKCDLBMWMSNIACCUCMSVZVCPNPSNLcelCSNTSpinal nerve transectionhuman immunodeficiency virus type IALBPTPCFATNFαEPMERKPFCBLAcomplete Freund's adjuvantBDNFCeAforced swim testchronic constriction injurySpared nerve injuryEmotional disordercognitive impairmentUnpredictable chronic mild stressstreptozotocinlong-term depressionMRIelevated plus mazeBrdUbromodeoxyuridineMagnetic resonance imaginglong-term potentiationLTPtumor necrosis factor αAnimalschronic painCNSAnxiety-like behaviorDepression-like behaviorBee venomcentral nervous systemdentate gyruscorticotropin-releasing factorcommon peroneal nerveBrain-derived neurotrophic factorprefrontal cortexprimary somatosensory cortexinsular cortexanterior cingulate cortexMorris water mazeLTDOpen fieldComorbidityHIV-1Varicella zoster virusexcitatory postsynaptic potentialsPost-tetanic potentiationProtein kinase CSynaptic plasticityspinal nerve ligationPartial sciatic nerve ligationextracellular signal-regulated kinase
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Authors
Ming-Gang Liu, Jun Chen,