Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353607 | Progress in Neurobiology | 2010 | 11 Pages |
Abstract
Evidence accumulates for a key role of the β2-adrenergic receptors in the many homeostatic and neuroprotective functions of astrocytes, including glycogen metabolism, regulation of immune responses, release of neurotrophic factors, and the astrogliosis that occurs in response to neuronal injury. A dysregulation of the astrocytic β2-adrenergic-pathway is suspected to contribute to the physiopathology of a number of prevalent and devastating neurological conditions such as multiple sclerosis, Alzheimer's disease, human immunodeficiency virus encephalitis, stroke and hepatic encephalopathy. In this review we focus on the physiological functions of astrocytic β2-adrenergic receptors, and their possible impact in disease states.
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Neuroscience (General)
Authors
Guy Laureys, Ralph Clinckers, Sarah Gerlo, Anneleen Spooren, Nadine Wilczak, Ron Kooijman, Ilse Smolders, Yvette Michotte, Jacques De Keyser,