| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 4353723 | Progress in Neurobiology | 2010 | 19 Pages |
Abstract
The allosteric control of G-protein coupled receptors is examined in the light of the new views on allosterism and recent data on a homocysteine analogue capable of modulating D2 receptors are shown. Finally, the hypothesis is introduced on the existence of check-points along the amino acid pathways connecting allosteric and orthosteric binding sites of a receptor and their potential importance for drug development.
Keywords
AFMRRILTFUCP2Hcyreceptor–receptor interactionsGPCRscpsMORG-protein coupled receptorsAllosterismlong-term depressionVolume transmissionChoParkinson's diseaseChinese Hamster Ovarylong-term facilitationlong-term potentiationLTPDORDopamineaggregation indextransmembrane helixLTDReceptor Mosaicatomic force microscopyhomocysteineKORuncoupling protein 2delta opioid receptorskappa opioid receptorsmu Opioid receptors
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Authors
Luigi F. Agnati, Diego Guidolin, Giuseppina Leo, Chiara Carone, Susanna Genedani, Kjell Fuxe,