Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353736 | Progress in Neurobiology | 2008 | 20 Pages |
Abstract
Here we present an overview of the experimental data regarding synaptic plasticity in the basal ganglia and highlight how results reported in the literature are often contradictory, especially when compared to those obtained in the hippocampal area. In trying to propose possible explanations to some of these contradictions, we present a holistic approach that re-interprets the basal ganglia synaptic plasticity in terms of expression of physiological and pathological phenomena and therapeutic effects of drugs.
Keywords
cdk5α-amino-3-hydroxy-5-methyl-isoxazole-4-propionatemGluR1/5Glutamate receptor subunitsGroup II metabotropic glutamate receptorGroup I metabotropic glutamate receptorNR2BLFSN-methyl-d-aspartic acid3-NPHFSDBSNMDACB1AMPAnAChRNACERK3-nitropropionic acidcAMPEPSPl-DOPAmGluR2/3Cyclic adenosine monophosphateγ-aminobutyric acidlong-term depressionHuntington's diseaselow-frequency stimulationdeep brain stimulationhigh-frequency stimulationlong-term potentiationLTPDopaminecyclin-dependent kinase 5levodopaLTDmedium spiny neuronNucleus accumbensexcitatory postsynaptic potentialextracellular signal-regulated kinaseGABAnicotinic acetylcholine receptor
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Authors
Nicola Berretta, Robert Nisticò, Giorgio Bernardi, Nicola Biagio Mercuri,