Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353784 | Progress in Neurobiology | 2009 | 12 Pages |
Abstract
Since the concept of fetal origins of adult diseases was introduced in 1980s, the development of the renin-angiotensin system (RAS) in normal and abnormal patterns has attracted attention. Recent studies have shown the importance of the fetal RAS in both prenatal and postnatal development. This review focuses on the functional development of the fetal brain RAS, and ontogeny of local brain RAS components in utero. The central RAS plays an important role in the control of fetal cardiovascular responses, body fluid balance, and neuroendocrine regulation. Recent progress has been made in demonstrating that altered fetal RAS development as a consequence of environmental insults may impact on “programming” of hypertension later in life. Given that the central RAS is of equal importance to the peripheral RAS in cardiovascular regulation, studies on the fetal brain RAS development in normal and abnormal patterns could shed light on “programming” mechanisms of adult cardiovascular diseases in fetal origins.
Keywords
MABPNGFSHP-1ICVintracerebroventricularSupraoptic nucleiMNPOGTPγSAT2RECoGNTSOVLTAT1RAVPCVOsPRLLPBNHPDACTHDEXCorticotropin releasing factor receptorACEhAGTRASSFOCRFCRF-R1ATIPTSHIGF-Iangiotensin converting enzymeangiotensinelectrocorticogramcircumventricular organsoxytocinAngCNSDexamethasoneDevelopmentgestation dayBBBRenin–angiotensin systemcentral nervous systemarea postremacorticotropin-releasing factorSubfornical organnerve growth factorinsulin-like growth factor 1SONmean arterial blood pressurePVNblood–brain-barrierHypothalamic-pituitary-adrenal axisFetal brainHPAlateral parabrachial nucleusParaventricular nucleimedian preoptic nucleusadrenocorticotropic hormoneThyroid-stimulating hormoneGrowth hormonearginine vasopressinProlactin
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Caiping Mao, Lijun Shi, Feichao Xu, Lubo Zhang, Zhice Xu,