Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4353908 | Progress in Neurobiology | 2008 | 26 Pages |
Abstract
Several exciting approaches for restorative therapy in Parkinson's disease have emerged over the past two decades. This review initially describes experimental and clinical data regarding growth factor administration. We focus on glial cell line-derived neurotrophic factor (GDNF), particularly its role in neuroprotection and in regeneration in Parkinson's disease. Thereafter, we discuss the challenges currently facing cell transplantation in Parkinson's disease and briefly consider the possibility to continue testing intrastriatal transplantation of fetal dopaminergic progenitors clinically. We also give a more detailed overview of the developmental biology of dopaminergic neurons and the potential of certain stem cells, i.e. neural and embryonic stem cells, to differentiate into dopaminergic neurons. Finally, we discuss adult neurogenesis as a potential tool for restoring lost dopamine neurons in patients suffering from Parkinson's disease.
Keywords
Lmx1aCNTFFGFNCSDATNGFPSA-NCAMGDNFNurr1AAVGIRK2SGZSVZTGFMPTPWnt1CD45OTX2NTNMSX1VMAT2Ngn2Engrailedgbx2Pitx3MASH1LIFNT4/5bFGF6-OHDAEGFIGF6-HydroxydopamineBDNFl-DOPAneuroDAdenovirusStriatumDopamine transporterHumanParkinson's diseaseTATtransforming growth factorEnzyme-linked immunosorbent assayELISAsubstantia nigraPositron emission tomographytyrosine hydroxylaseEmbryonicfetalembryoid bodiesESCcluster of differentiation 45ShhTherapyembryonic dayBBBBlood–brain barrierStem cellEmbryonic stem cellNeural stem cellsonic hedgehogepidermal growth factorTranscription factorleukemia inhibitory factorGrowth factornerve growth factorfibroblast growth factorbasic fibroblast growth factorInsulin-like growth factorGlial cell line-derived neurotrophic factorBrain-derived neurotrophic factorciliary neurotrophic factorFoxaFluorodopaminelevodopaCerebrospinal fluidCSFsubgranular zonesubventricular zoneMousevesicular monoamine transporter 2neurotrophin-4/5neurturinNeurogenesisNeurogenin 2Adeno-associated virusLentivirusPETGraftTransplantation
Related Topics
Life Sciences
Neuroscience
Neuroscience (General)
Authors
Tomas Deierborg, Denis Soulet, Laurent Roybon, Vanessa Hall, Patrik Brundin,