Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4354364 | Trends in Neurosciences | 2013 | 11 Pages |
Abstract
DNA methylation was once considered to be a static epigenetic modification whose primary function was restricted to directing the development of cellular phenotype. However, it is now evident that the methylome is dynamically regulated across the lifespan: during development as a putative mechanism by which early experience leaves a lasting signature on the genome and during adulthood as a function of behavioral adaptation. Here, we propose that experience-dependent variations in DNA methylation, particularly within the context of learning and memory, represent a form of genomic metaplasticity that serves to prime the transcriptional response to later learning-related stimuli and neuronal reactivation.
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Authors
Danay Baker-Andresen, Vikram S. Ratnu, Timothy W. Bredy,