Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
4354575 | Trends in Neurosciences | 2009 | 9 Pages |
Abstract
In addition to radial glial cells of neurohistogenesis, immature astrocytes with stem-cell-like properties cordon off emerging functional patterns in the developing brain. Astrocytes also can be stem cells during adult neurogenesis, and a proposed potency of injury-associated reactive astrocytes has recently been substantiated. Astrocytic cells might additionally be involved in cancer stem cell-associated gliomagenesis. Thus, there are distinguishing roles for stem-cell-like astrocytes during brain development, in neurogenic niches in the adult, during attempted reactive neurogenesis after brain injury or disease and during brain tumorigenesis.
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Authors
Daniel J. Silver, Dennis A. Steindler,